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Sites of pain from interstitial cystitis/painful bladder syndrome. Warren JW, Langenberg P, Greenberg P, et al. J Urol 2008 Aug 14. [Epub ahead of print] PMID: 18707715
• multiple pain sites are common in IC/PBS
• in this study the authors hypothesized that careful and systematic description might provide clues to its pathogenesis
• they concluded that suprapubic prominence and changes in the voiding cycle are features consistent with but do not prove that the bladder is the pain generator in IC/PBS and the pain sites described by patients are referred from it
Cross-organ interactions between reproductive, gastrointestinal and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve. Winnard KP, Dmitrieva N, Berkley KJ. Am J Physiol Regul Integr Comp Physiol 2006;291:R1592-601
• inflaming one pelvic organ in rats could produce estrous-modifiable signs of inflammation in other pelvic organs, particularly bladder, suggesting that the cross-organ effects involve the hypogastric nerve and are at least partly centrally mediated
• the authors suggest that such effects could contribute to cooccurrence and cyclicity of distressing pelvic disorders in women
A life of pelvic pain Berkley KJ. Physiol Behav 2005;86:272-80
PMID: 16139851
The pains of endometriosis. Berkley KJ, Rapkin AJ, Papka RE. Science 2005;308(5728):1587-9
PMID: 15947176
Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Parsons CL. Urology 2005;65:45-8
PMID: 15667861
Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia. Henry R, Patterson L, Avery N, et al. J Urol 2001;165(6 Pt 1):1900-3
PMID: 11371877
