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Ketamine-Associated Ulcerative Cystitis: A New Clinical Entity. Shahani R, Streutker C, Dickson B, Stewart RJ. Urology 2007;69:810-2 • ketamine is an anesthetic agent that is increasingly being used as a recreational drug
• the authors describe a series of 9 patients, all of whom were daily ketamine users, who presented with severe dysuria, frequency, urgency, and gross hematuria; the urine cultures were sterile in all cases
• CT revealed marked thickening of the bladder wall, a small capacity, and perivesicular stranding, consistent with severe inflammation; at cystoscopy, all patients had severe ulcerative cystitis.
• biopsies in 4 patients revealed epithelial denudation and inflammation with a mild eosinophilic infiltrate
• cessation of ketamine use, with the addition of pentosan polysulfate, appeared to provide some symptomatic relief
Region-specific changes in the phosphorylation of ERK1/2 and ERK5 in rat micturition pathways following cyclophosphamide-induced cystitis. Qiao LY, Gulick MA. Am J Physiol Regul Integr Comp Physiol 2006 Nov 16; [Epub ahead of print]
PMID: 17110531
Up-regulation of interleukin-6 gene expression in cyclophosphamide-induced cystitis in mice: An in situ hybridization histochemical study. Nishii H, Nomura M, Fujimoto N, Matsumoto T. Int J Urol 2006;13:1339-43
PMID: 17010015
Peptodergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis. Dickson A, Avelino A, Cruz F, Ribeiro-da-Silva A. Neuroscience 2006;141:1633-47
PMID: 16989017
Indomethacin-induced morphologic changes in the rat urinary bladder epithelium. Cetinel S, Cetinel B, ERcan F, et al. Urology 2003;61:236-42
PMID: 12559315
Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. Malley SE, Vizzard MA. Physiol Genomics 2002;9:5-13
PMID: 11948286
Clinical features of tiaprofenic acid (surgam) associated cystitis and a study of risk factors for its development. Buchbinder R, Forbes A, Kobben F, et al. J Clin Epidemiol 2000;53:1013-9
PMID: 11027933
Drug-induced bladder and urinary disorders. Incidence, prevention and management. Drake MJ, Nixon PM, Crew JP. Drug Saf 1998;19:45-55
PMID: 9673857
Cystitis associated with tiaprofenic acid: a survey of British and Irish urologists. Henley MJ, Harriss D, Bishop MC. Br J Urol 1997;79:585-7
PMID: 9126087
Tiaprofenic acid: an uncommon cause of cystitis often misdiagnosed as interstitial cystitis. Heritz DM, Thiessen JJ. Can J Urol 1996;3:202-205
PMID: 12741979
[Eosinophilic cystitis induced by tranilast: a case report] (in Japanese) Sakai N, Yamada T, Murayama T. Hinyokika Kiyo 1998;44:45-7
PMID: 9503209
Eosinophilic cystitis induced by mitomycin-C. Ulker V, Apaydin E, Gursan A, et al. Int Urol Nephrol 1996;28:755-9
PMID: 9089042
