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selected literature on drug-induced cystitis    
click on the title to jump to the abstract if available
  • Ketamine-Associated Ulcerative Cystitis: A New Clinical Entity.
    Shahani R, Streutker C, Dickson B, Stewart RJ. Urology 2007;69:810-2
    • ketamine is an anesthetic agent that is increasingly being used as a recreational drug
    • the authors describe a series of 9 patients, all of whom were daily ketamine users, who presented with severe dysuria, frequency, urgency, and gross hematuria; the urine cultures were sterile in all cases
    • CT revealed marked thickening of the bladder wall, a small capacity, and perivesicular stranding, consistent with severe inflammation; at cystoscopy, all patients had severe ulcerative cystitis.
    • biopsies in 4 patients revealed epithelial denudation and inflammation with a mild eosinophilic infiltrate
    • cessation of ketamine use, with the addition of pentosan polysulfate, appeared to provide some symptomatic relief
  • Region-specific changes in the phosphorylation of ERK1/2 and ERK5 in rat micturition pathways following cyclophosphamide-induced cystitis.
    Qiao LY, Gulick MA. Am J Physiol Regul Integr Comp Physiol 2006 Nov 16; [Epub ahead of print]
    PMID: 17110531
  • Up-regulation of interleukin-6 gene expression in cyclophosphamide-induced cystitis in mice: An in situ hybridization histochemical study.
    Nishii H, Nomura M, Fujimoto N, Matsumoto T. Int J Urol 2006;13:1339-43 PMID: 17010015
  • Peptodergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis.
    Dickson A, Avelino A, Cruz F, Ribeiro-da-Silva A. Neuroscience 2006;141:1633-47 PMID: 16989017
  • Indomethacin-induced morphologic changes in the rat urinary bladder epithelium.
    Cetinel S, Cetinel B, ERcan F, et al. Urology 2003;61:236-42 PMID: 12559315
  • Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
    Malley SE, Vizzard MA. Physiol Genomics 2002;9:5-13 PMID: 11948286
  • Clinical features of tiaprofenic acid (surgam) associated cystitis and a study of risk factors for its development.
    Buchbinder R, Forbes A, Kobben F, et al. J Clin Epidemiol 2000;53:1013-9 PMID: 11027933
  • Drug-induced bladder and urinary disorders. Incidence, prevention and management.
    Drake MJ, Nixon PM, Crew JP. Drug Saf 1998;19:45-55 PMID: 9673857
  • Cystitis associated with tiaprofenic acid: a survey of British and Irish urologists.
    Henley MJ, Harriss D, Bishop MC. Br J Urol 1997;79:585-7 PMID: 9126087
  • Tiaprofenic acid: an uncommon cause of cystitis often misdiagnosed as interstitial cystitis.
    Heritz DM, Thiessen JJ. Can J Urol 1996;3:202-205 PMID: 12741979
  • [Eosinophilic cystitis induced by tranilast: a case report] (in Japanese)
    Sakai N, Yamada T, Murayama T. Hinyokika Kiyo 1998;44:45-7 PMID: 9503209
  • Eosinophilic cystitis induced by mitomycin-C.
    Ulker V, Apaydin E, Gursan A, et al. Int Urol Nephrol 1996;28:755-9 PMID: 9089042
  • Intravesical thiotepa-induced eosinophilic cystitis.
    Choe JM, Kirkemo AK, Sirls LT. Urology 1995;46:729-31 PMID: 7495132
    • review.
  • Severe cystitis associated with tiaprofenic acid.
    Crawford ML, Waller PC, Wood SM. Br J Urol 1997;79:578-84 PMID: 9126086
  • Tiaprofenic acid as a cause of non-bacterial cystitis.
    O’Neill GF. Med J Aust 1994;160:123-5 PMID: 8295577
  • Cystitis and nonsteroidal anti-inflammatory drugs: an incidental association or an adverse effect?
    Ghose K. N Z Med J 1993;106:501-3 PMID: 8247434






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