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selected literature on PBS/IC and diagnostic markers    
 
antiproliferative factor
 
  • Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis.
    Graham E, Chai TC. Curr Urol Rep. 2006;7:440-6. Review PMID: 17052438
  • CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients.
    Conrads TP, Tocci GM, Hood BL, et al. J Biol Chem 2006 Oct 8; PMID: 17030514
  • Urinary and serologic markers for interstitial cystitis: an update.
    Wilkinson DR, Erickson AD. Curr Urol Rep 2006;7:414-22 PMID: 16959181
  • Symposium report on urothelial dysfunction: pathophysiology and novel therapies.
    Kani A, de Groat W, Birder L, et al. J Urol 2006;175:1624-9
  • APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis.
    Zhang CO, Li ZL, Kong CZ. BMC Urol 2005;5:7 PMID: 15862132
  • An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide
    Keay SK, Szekely Z, Conrads TP, et al. Proc Natl Acad Sci USA 2004;101:11803-8 PMID: 15282374
  • Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator.
    Rashid HH, Reeder JE, O’Connell MJ, et al. BMC Urol 2004;4:3 PMID: 15068487
  • Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndrome.
    Keay S, Zhang CO, Chai T, et al. Urology 2004;63:22-6 PMID: 14751340
  • Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment.
    Keay S, Seillier-Moiseiwitsch F, Zhang CO, et al. Physiol Genomics 20037;14:107-15 PMID: 12847144
  • Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis.
    Keay S, Zhang CO, Shoenfelt JL, Chai TC. Urology. 2003 Jun;61(6):1278-84 PMID: 12809929
  • A comparison of multiple urine markers for interstitial cystitis.
    Erickson DR, Xie SX, Bhavanandan VP, Wheeler MA, Hurst RE, Demers LM, Kushner L, Keay SK. J Urol. 2002 Jun;167(6):2461-9. PMID: 11992058
  • Urine markers of interstitial cystitis
    Erickson DR. Urology 2001;57(6 Suppl 1):15-21 PMID: 11378044
  • Sensitivity and specificity of antiproliferative factor, heparin-binding peridermal growth factor-like factor, and epidermal growth factor as urine markers for interstitial cystitis.
    Keay SK, Zhang CO, Shoenfelt J, et al. Urology 2001;57(6 Suppl 1):9-14 PMID: 11378043
  • Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients.
    Keay S, Warren JW, Zhang CO, et al. J Urol 1999;162:1487-9 PMID: 10492242
  • Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis.
    Chai TC, Zhang CO, Shoenfelt JL, Johnson HW Jr, Warren JW, Keay S. J Urol. 2000 May;163(5):1440-4. PMID: 10751853
  • Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production.
    Keay S, Kleinberg M, Zhang CO, Hise MK, Warren JW. J Urol. 2000 Dec;164(6):2112-8. PMID: 11061938
  • Percutaneous sacral third nerve root neurostimulation improves symptoms and normalizes urinary HB-EGF levels and antiproliferative activity in patients with interstitial cystitis.
    Chai TC, Zhang CO, Warren JW, Keay S. Urology. 2000 May;55(5):643-6. PMID: 10792070
 
other
 
  • Urinary and serologic markers for interstitial cystitis: an update.
    Wilkinson DR, Erickson AD. Curr Urol Rep 2006;7:414-22 PMID: 16959181
  • Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity.
    Lokeshwar VB, Selzer MG, Unwala DJ, et al. J Urol 2006;176:1001-7 PMID: 16890679
  • Urinary urinate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity.
    Lokeshwar VB, Selzer MG, Cerwinka WH, et al. J Urol 2005;174:344-9 PMID: 15947687
  • APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis.
    Zhang CO, Li ZL, Kong CZ. BMC Urol 2005;5:7 PMID: 15862132
  • Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis.
    Hosseini A, Ehren I, Wiklund NP. J Urol 2004;172(6 Pt 1):2261-5 PMID: 15538244
  • New theories in interstitial cystitis.
    Chai TC, Keay S. Nat Clin Pract Uro. 2004;1:85-9 Review. PMID: 16474520
  • A comparison of multiple urine markers for interstitial cystitis.
    Erickson DR, Xie SX, Bhavanandan VP, et al. J Urol. 2002;167:2461-9 PMID: 11992058
  • Interstitial cystitis – epidemiology, diagnostic criteria, clinical markers.
    Hanno PM. Rev Urol 2002;4 Suppl 1:S3-8 PMID: 16986032
  • Sensitivity and specificity of antiproliferative factor, heparin-binding peridermal growth factor-like factor, and epidermal growth factor as urine markers for interstitial cystitis.
    Keay SK, Zhang CO, Shoenfelt J, et al. Urology 2001;57(6 Suppl 1):9-14 PMID: 11378043
  • Urine markers of interstitial cystitis
    Erickson DR. Urology 2001;57(6 Suppl 1):15-21 PMID: 11378044
 
 
       
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