Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis. Graham E, Chai TC. Curr Urol Rep. 2006;7:440-6. Review
PMID: 17052438
CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. Conrads TP, Tocci GM, Hood BL, et al. J Biol Chem 2006 Oct 8;
PMID: 17030514
Urinary and serologic markers for interstitial cystitis: an update. Wilkinson DR, Erickson AD. Curr Urol Rep 2006;7:414-22
PMID: 16959181
Symposium report on urothelial dysfunction: pathophysiology and novel therapies. Kani A, de Groat W, Birder L, et al. J Urol 2006;175:1624-9
APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis. Zhang CO, Li ZL, Kong CZ. BMC Urol 2005;5:7
PMID: 15862132
An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide Keay SK, Szekely Z, Conrads TP, et al. Proc Natl Acad Sci USA 2004;101:11803-8
PMID: 15282374
Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator. Rashid HH, Reeder JE, O’Connell MJ, et al. BMC Urol 2004;4:3
PMID: 15068487
Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndrome. Keay S, Zhang CO, Chai T, et al. Urology 2004;63:22-6
PMID: 14751340
Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment. Keay S, Seillier-Moiseiwitsch F, Zhang CO, et al. Physiol Genomics 20037;14:107-15
PMID: 12847144
Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis. Keay S, Zhang CO, Shoenfelt JL, Chai TC. Urology. 2003 Jun;61(6):1278-84
PMID: 12809929
A comparison of multiple urine markers for interstitial cystitis. Erickson DR, Xie SX, Bhavanandan VP, Wheeler MA, Hurst RE, Demers LM, Kushner L, Keay SK. J Urol. 2002 Jun;167(6):2461-9.
PMID: 11992058
Urine markers of interstitial cystitis Erickson DR. Urology 2001;57(6 Suppl 1):15-21
PMID: 11378044
Sensitivity and specificity of antiproliferative factor, heparin-binding peridermal growth factor-like factor, and epidermal growth factor as urine markers for interstitial cystitis. Keay SK, Zhang CO, Shoenfelt J, et al. Urology 2001;57(6 Suppl 1):9-14
PMID: 11378043
Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients. Keay S, Warren JW, Zhang CO, et al. J Urol 1999;162:1487-9
PMID: 10492242
Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis. Chai TC, Zhang CO, Shoenfelt JL, Johnson HW Jr, Warren JW, Keay S. J Urol. 2000 May;163(5):1440-4.
PMID: 10751853
Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production. Keay S, Kleinberg M, Zhang CO, Hise MK, Warren JW. J Urol. 2000 Dec;164(6):2112-8.
PMID: 11061938
Percutaneous sacral third nerve root neurostimulation improves symptoms and normalizes urinary HB-EGF levels and antiproliferative activity in patients with interstitial cystitis. Chai TC, Zhang CO, Warren JW, Keay S. Urology. 2000 May;55(5):643-6.
PMID: 10792070
other
Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis. Lamale LM, Lutgendorf SK, Zimmerman MB, Kreder KJ. Urology 2006;68:702-6
• the authors conclude that a combination of methylhistamine and IL-6 could be used as a sensitive and specific marker for interstitial cystitis; however, the sensitivity of 70.0% and specificity of 72.4% do not seem good enough for their use in clinical practice
Urinary and serologic markers for interstitial cystitis: an update. Wilkinson DR, Erickson AD. Curr Urol Rep 2006;7:414-22
PMID: 16959181
Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity. Lokeshwar VB, Selzer MG, Unwala DJ, et al. J Urol 2006;176:1001-7
PMID: 16890679
Urinary urinate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity. Lokeshwar VB, Selzer MG, Cerwinka WH, et al. J Urol 2005;174:344-9
PMID: 15947687
APF, HB-EGF, and EGF biomarkers in patients with ulcerative vs. non-ulcerative interstitial cystitis. Zhang CO, Li ZL, Kong CZ. BMC Urol 2005;5:7
PMID: 15862132
Nitric oxide as an objective marker for evaluation of treatment response in patients with classic interstitial cystitis. Hosseini A, Ehren I, Wiklund NP. J Urol 2004;172(6 Pt 1):2261-5
PMID: 15538244
New theories in interstitial cystitis. Chai TC, Keay S. Nat Clin Pract Uro. 2004;1:85-9 Review.
PMID: 16474520
A comparison of multiple urine markers for interstitial cystitis. Erickson DR, Xie SX, Bhavanandan VP, et al. J Urol. 2002;167:2461-9
PMID: 11992058
