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selected literature on cross-talk/cross-organ interaction    
  • Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides.
    Ustinova EE, Gutkin DW, Pezzone MA. Am J Physiol Renal Physiol 2007;292(1):F123-30 PMID: 16926445
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level.
    Christianson JA, Liang R, Ustinova EE, et al. Pain 2006 Oct 26; [Epub ahead of print]
    PMID: 17070995
  • Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization.
    Ustinova EE, Fraser MO, Pezzone MA. Am J Physiol Renal Physiol 2006;290(6):F1478-87 PMID: 16403832
  • Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk.
    Malykhina AP, Qin C, Greenwood-van Meerveld B, et al. Neurogastroenterol Motil 2006;18:936-48 PMID: 16961697
  • Cross-organ sensitization of lumbosacral spinal neurons receiving urinary bladder input in rats with inflamed colon.
    Qin C, Malykhina AP, Akbarali HI, Foreman RD. Gastroenterology 2005;129:1967-78 PMID: 16344065
  • A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders.
    Pezzone MA, Liang R, Fraser MO. Gastroenterology 2005;128:1953-64 PMID: 15940629



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